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An additional argument is a direct demonstration of the healing of the severely injured muscles (15-17) and severely injured nerves (18) and brain injuries (19-23) not relied on immunomodulation

Regular movement and light exercise generate internal heat and can offset the thermoregulatory shifts induced by tirzepatide

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The authors also acknowledge Francesco Zaccardi (PhD, Clinical Research Fellow, University of Leicester, Leicester, UK) and David Kloecker (Medical Student, University of Leicester) who assisted with extracting PubMed articles and identifying relevant records by title and abstract